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Melinta Therapeutics continues its aggressive promotion of the new fluoroquinolone delafloxacin, marketed under the brand name Baxdela.

Melinta is touting Baxela as being robust and safe with no cases of C. difficile diarrhea or Baxdela-related cases of tendinitis or tendon rupture, peripheral neuropathy or myopathy found in the phase three trials, undoubtedly company sponsored.

With the rise of superbugs and the current worldwide formulary of available antibiotics limited, the field of anti-infectives is ripe and willing to accept all newcomers, it is unfortunate that one of those newcomers has to be a fluoroquinolone.

As Baxdela proceeds through phase 3 trials with glowing reviews it appears that, unfortunately, we will have to prepare for those unfortunate souls in the future who will fall prey to FQAD. Since their inception, over half of the officially released FQ's have been taken off of the market due to adverse events, and all the remaining have the propensity to cause horrific adverse events. It is my opinion, since Baxdela is undoubtedly based off of the quinoline pharmacophore, it will have the same propensity for adverse events.

In an Ironic twist, they still put the safety caveat on Baxdela: "IMPORTANT SAFETY INFORMATION: WARNING: SERIOUS ADVERSE REACTIONS INCLUDING TENDINITIS, TENDON RUPTURE, PERIPHERAL NEUROPATHY, CENTRAL NERVOUS SYSTEM EFFECTS, AND EXACERBATION OF MYASTHENIA GRAVIS Discontinue Baxdela immediately and avoid the use of fluoroquinolones, including Baxdela, in patients who experience any of these serious adverse reactions." What they don't tell anyone is, once a patient experiences one of these adverse events, stopping the medication will not undue the damage already done.

Baxdella was one of six new quinolones that are in development that I wrote about in July of this year.
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To my most ardent critic in the medical profession, you know who you are, who calls my claims of the fluoroquinolones as being chemotherapy (anti-cancer or anti-tumor), "sensationalism" and "pure speculation", here are some links for your edification:

I could post many more, but these should be enough to defend my position. I know that it is cliché, but knowledge is power. Here's a thought, instead of criticizing, why not use critical thinking instead and look at the merits of the argument despite your presuppositions.

When researchers from within your own field have already developed an anti-cancer quinolone, based off of Levaquin scaffold as I recall, and that product is currently on the market, your argument becomes untenable and reduced to baseless criticism.
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This website was created to chronicle my experience, observations, and opinions, as I travel through life with damage received after having an adverse event to a fluoroquinolone (FQ) antibiotic, Levaquin. This blog is the second oldest blog of it’s type and is a true grass root’s project, not designed to generate web traffic, income, sell books, or promote lawyers, but instead dedicated to the thousands each year who become chronically affected and disabled by these prescription drugs. This supposed “safe” class of antibiotics are given out in hundreds and thousands of prescriptions daily around the world for routine needs.  Unbeknownst to many, these drugs can cause horrific adverse events that can disable the most healthy of individuals creating long lasting injuries.  These adverse events are considered statistically insignificant by drug companies and the FDA, even though their rate of occurrence is fairly high.
Often the victims do not know what has befallen them, not suspecting that these drugs could be the cause of their symptoms, especially in those individuals who experience health issues months or years after ingestion. Compounding the problem, the medical community is woefully ignorant to their effects and the long term damages making the suffering endured by these drugs greatly increased. The FDA knows how dangerous these drugs are, and have coined an acronym FQAD (Fluoroquinolone Associated Disability) for the symptoms they see. However, and quite unfortunately, they refuse to act in a responsible manner that would help safeguard the general public. Currently there is no medical cure and no magic bullet.
Join me as a blog about research, advocacy, and living life after the FQs.  I collect stats on those who are chronically suffering after taking FQ’s. If you are new to this plight, please use caution when treading the Internet waters, the information can be overwhelming, opinions vary, and emotions run high. Unfortunately, like many other Internet communities, there are strong inter-community politics and camps of ideas which should  be also approached lightly by the newcomer.   Having said that, those that are in true need of help and are seeking honest answers to their plight can usually find help and solace. If you are new and want to know What is Floxing?, click here.  Other links that may help is my Guide to Facebook Groups, FQ Faq, the popular What Helps page, which is information gleaned from the floxed community and its free.  
I receive dozens of emails each week regarding fluoroquinolones, many from newly affected individuals.  Many times it is impossible for me to return all emails in a timely manner, but I try my best.  Please subscribe to my email list using the form in the right hand column.
Many people email me and ask how I am doing.  I have been dealing with this adverse event for well over ten years.  Although I worked for many years into my reaction I am now, for the most part, functionally disabled due to progressing chronic fatigue/mitochondrial/energy issues.  I have been dealing with what my doctor believes is drug induced mitochondrial disease/dysfunction.   I was able to take an early retirement.  Still, I have a family with young children which takes a large amount of my time, while suffering from severe physical problems of a dreaded delayed Levaquin adverse event.  Still, I like to communicate with those who are chronically suffering from reactions to these drugs to let them know they are not alone. Again, please note, unlike some others, this is a true grass roots blog, a little rough around the edges, not designed to act as an advertisement for law firms, up-sell products, or provide monetary gain, read my monetization policy or pledge.  May you have Godspeed on your journey.

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Metabolomics: Hope For Chronic Floxing?

I believe that metabolomics is going to open a door for giving us insight into chronic fluoroquinolone toxicity and provide insight into treatment options for those chronically suffering.


FDA Fails to Go The Distance, Yet Again

I am ecstatic about the new label changes. But given the FDA’s past track record, I will not happy until every medical professional, who has the ability to prescribe a FQ, is familiar with the label changes and safety precautions.


Six New Quinolones In Development

It is this author’s opinion, that anything based on the quinoline pharmacophore synthetic or not, whose history can be traced all the way back to the cinchona tree, has a unique propensity for toxic damage in the human body.


FDA Shell Game? I Hope Not

I think it was no coincidence that the FDA denied the mitochondrial citizen petition during the same time frame that they approved label changes. Right now the FDA is not acknowledging even the risk of mitochondrial toxicity.