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How can the FQ's cause different disease processes?

This happens because of the complex interaction that exists between the hundreds of genes and cells that work together to keep the body’s metabolic machinery running smoothly. Just like many mitochondrial diseases that produce varying clinical manifestations from identical mtDNA mutations, FQ's, who influence the mitochondria extensively, may not produce identical clinical manifestations. Therefore, two people can take the same FQ, the same dose, and experience an adverse event but may not look the same clinically, which complicates diagnosis.
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"I wish every time a provider wrote a prescription for a quinolone they were forced to also write on the prescription the type of infection being treated, if there were confirmed microbial cultures growing pseudomonas, and if the patient has drug allergies. That way, the provider will be forced to put more thought into prescribing cipro. Also, the pharmacist can double check if the situation is complicated and serious, or simple and easily cured with a safer antibiotic." ~ Gunda Siska, PharmD

Another good idea to get doctor's thinking!

www.pharmacytimes.com/contributor/gunda-siska-pharmd/2017/08/putting-a-face-on-black-box-warnings
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Do the FQ’s always do damage to DNA for their adverse effects to be experienced long term or chronic?

No. While it is true that they can damage DNA (the subject for another post), their long term negative effects can also be experienced via epigenetic changes. With epigenetic changes, the DNA is not damaged per say, but instead genes which have the capability to cause unwanted health problems are either ‘turned on’ or ‘turned off’ in the right combination.

There is a myth that all mitochondrial diseases are maternally inherited. As a matter of fact most secondary mitochondrial disorders (those experienced by adults later on in life such as floxies), are the result of another process, such as a toxin (FQ) exposure. Many floxies who are chronically effected long term are good examples for adult mitochondrial dysfunction. According to respected mitochondrial disease expert Bruce Cohen M.D. of the Akron Children’s Hospital, formerly of the Cleveland Clinic, these secondary mitochondrial disorders are the result of nuclear DNA that has been activated in the right combination to become pathologic. In and of themselves, these genes are not pathologic until there is another trigger (an epigenetic factor). Remember, the FQ’s are very metabolically intense, with the ability to affect millions of points within the human body. It is what makes them both effective and deadly at the same time. This is why their adverse effects can appear long after cessation of the drug.
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I know we get tired of petitions to the point of complacency. However, please, have everyone you know sign this petition. Those who reap obscene profits, not by normal healthy capitalistic ways, but instead by corrupt influence of governmental regulation need to be held accountable. They are the reason why some of these drugs stay on the market despite serious health concerns.

www.change.org/p/u-s-department-of-justice-do-you-need-financial-help-due-to-a-medication-side-ef...
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Welcome

This website was created to chronicle my experience, observations, and opinions, as I travel through life with damage received after having an adverse event to a fluoroquinolone (FQ) antibiotic, Levaquin. This blog is the second oldest blog of it’s type and is a true grass root’s project, not designed to generate web traffic, income, sell books, or promote lawyers, but instead dedicated to the thousands each year who become chronically affected and disabled by these prescription drugs. This supposed “safe” class of antibiotics are given out in hundreds and thousands of prescriptions daily around the world for routine needs.  Unbeknownst to many, these drugs can cause horrific adverse events that can disable the most healthy of individuals creating long lasting injuries.  These adverse events are considered statistically insignificant by drug companies and the FDA, even though their rate of occurrence is fairly high.
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Often the victims do not know what has befallen them, not suspecting that these drugs could be the cause of their symptoms, especially in those individuals who experience health issues months or years after ingestion. Compounding the problem, the medical community is woefully ignorant to their effects and the long term damages making the suffering endured by these drugs greatly increased. The FDA knows how dangerous these drugs are, and have coined an acronym FQAD (Fluoroquinolone Associated Disability) for the symptoms they see. However, and quite unfortunately, they refuse to act in a responsible manner that would help safeguard the general public. Currently there is no medical cure and no magic bullet.
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Join me as a blog about research, advocacy, and living life after the FQs.  I collect stats on those who are chronically suffering after taking FQ’s. If you are new to this plight, please use caution when treading the Internet waters, the information can be overwhelming, opinions vary, and emotions run high. Unfortunately, like many other Internet communities, there are strong inter-community politics and camps of ideas which should  be also approached lightly by the newcomer.   Having said that, those that are in true need of help and are seeking honest answers to their plight can usually find help and solace. If you are new and want to know What is Floxing?, click here.  Other links that may help is my Guide to Facebook Groups, FQ Faq, the popular What Helps page, which is information gleaned from the floxed community and its free.  
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I receive dozens of emails each week regarding fluoroquinolones, many from newly affected individuals.  Many times it is impossible for me to return all emails in a timely manner, but I try my best.  Please subscribe to my email list using the form in the right hand column.
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Many people email me and ask how I am doing.  I have been dealing with this adverse event for well over ten years.  Although I worked for many years into my reaction I am now, for the most part, functionally disabled due to progressing chronic fatigue/mitochondrial/energy issues.  I have been dealing with what my doctor believes is drug induced mitochondrial disease/dysfunction.   I was able to take an early retirement.  Still, I have a family with young children which takes a large amount of my time, while suffering from severe physical problems of a dreaded delayed Levaquin adverse event.  Still, I like to communicate with those who are chronically suffering from reactions to these drugs to let them know they are not alone. Again, please note, unlike some others, this is a true grass roots blog, a little rough around the edges, not designed to act as an advertisement for law firms, up-sell products, or provide monetary gain, read my monetization policy or pledge.  May you have Godspeed on your journey.
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