The following files are available for download or reading as a help to the fluoroquinolone victim community (in alphabetical order)
Dr. Charles Bennett Suicide Paper for the European Journal of Medicine July 20 2018 produced with help from the FQ community.
FDA Anti-Infective Drugs Advisory Committee UCM477657 Transcript 110515
FDA UCM365078 081503 Warnings of Permanent Peripheral Neuropathy
FDA Briefing Information Nov 5, 2015 Meeting of the Antimicrobial Drugs Advisory Committee and the Drug Safety and Risk Management Advisory Committee FQAD
4-Quinolones cause a selective loss of mitochondrial DNA from mouse L1210 leukemia cells.
Pew Trust Document showing Antibiotics Currently in Clinical Development as of May 2016
Drug Features That Contribute to the Activity of Quinolones against Mammalian Topoisomerase II and Cultured Cells: Correlation between Enhancement of Enzyme-Mediated DNA Cleavage In Vitro and Cytotoxic Potential Published in: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Oct. 1993,
Adverse Reactions to Fluoroquinolones, written by James Roberts M.D. 2008 Emergency Medicine Newsletter
Documents mtDNA damage in Nalidixic acid in 1983
Citizen Petition – Mitochondrial – Submitted by Dr. Bennett to FDA June 2014
Citizen Petition – Psychiatric – Submitted by Dr. Bennett to FDA Sept 2014
Genotoxic and cytotoxic effects of antibacterial drug, ciprofloxacin, on human lymphocytes in vitro. India 2008
Comprehensive Quinolone Drug Name List
This is a “Dear Colleague” letter written by Dr. Miriam J. de Jonge M.D. who herself was damaged by fluoroquinolones. I am posting this letter as a service to the FQ community at her request.
This is a “Dear Doctor” letter written by Dr. Todd Plumb M.D. who himself was damaged by fluoroquinolones. I am in no way associated with Dr. Plumb nor do I have any involvement in the writing of this letter. This is provided as an information download to the fluoroquinolone community.
Response to Dr. Charles Bennett from the FDA Dated July 10th, 2018 Detailing Psychiatric Changed to FQ Labels
Obtained by FOIA FDA Peripheral Neuropathy Internal Memo from 2013 considered by some to be a “smoking gun” in terms of the FDA acknowledging PN as being induced by mitochondrial damage.
Paper that shows the fluoroquinolones have a strong effect in decreasing mtDNA-encoded proteins in eukaryotic cells.
FLOX Report Rev. 12: Considered by some fluoroquinolone victims as the best informational document written on fluoroquinolone damage while others find it too depressing. Again I am in no way associated with the author, nor do I take any credit for the work. It is being provided here as an assistance to the fluoroquinolone victim community. Caution is advised
FLOX Report Rev. 12: Considered by some fluoroquinolone victims as the best informational document written on fluoroquinolone damage while others find it too depressing. Again I am in no way associated with the author, nor do I take any credit for the work. It is being provided here as an assistance to the fluoroquinolone victim community. Caution is advised.
Fluoroquinolone use was associated with an increased risk of aortic aneurysm or dissection. 2018 Study.
Fluoroquinolone Utilization in the Emergency Departments of Academic Medical Centers
Fluoroquinolone-related neuropsychiatric and mitochondrial toxicity: a collaborative investigation by scientists and members of a social network Published by Dr Bennett Feb 2016
Fluoroquinolone-induced serious, persistent, multisymptom adverse effects. A BMJ case study by Dr. Beartrice Golomb UCSD of which I participated.
Official Levaquin Package Insert
Pediatric Levaquin usage by the FDA.
Cellular Membrane Repair
Metal Complexes of Quinolone Antibiotics and Their Applications
Musculoskeletal Complications of Fluoroquinolones: Guidelines and Precautions for Usage in the Athletic Population written by Mederic M. Hall, MD, Jonathan T. Finnoff, DO, Jay Smith, MD from Mayo Clinic.
The Article “Peripheral Neuropathy Associated with Fluoroquinolones” written by Jay S Cohen M.D. and published in the Annals of Pharmacotherapy in December 2001.
Non-antibiotic effects of fluoroquinolones in mammalian cells. This important July 2015 Mayo paper documents that “FQ antibiotics induce global epigenetic changes”
Nonclassical Biological Activities of Quinolone Derivatives Nov. 2011
Dr Bennett & Sonar Citizen Petition Black Box Warning FQAD June 2019
Not Your Mother’s Mitochondrial Disease – Myths and Facts About Mitochondrial Cytopathies
Possible involvement of DEC1 on the adverse effects of quinolone antibiotics. China 2010
Quinolone binding to DNA is mediated by magnesium ions. India 1992
Do you know an important fluoroquinolone related document that belongs here to share with others? Contact me and let me know. Thanks.