Fluoroquinolone Use In The Emergency Room: Go To The ER And Get “Floxed”

The investigatory paper “Fluoroquinolone Utilization in the Emergency Departments of Academic Medical Centers Prevalence of, and Risk Factors for, Inappropriate Use” (1) poignantly highlights the need for greater Fluoroquinolone (FQ) oversight by the FDA and more judicious use by the medical establishment.

This study focused on 100 patients that were seen at the Emergency Rooms (ER) in two large academic hospitals and received a FQ antibiotic.ER_FQ

Of 100 total patients:

  • 81 received an FQ for an inappropriate indication!
    • Of the 81, 43 received a FQ when another antibiotic was considered first line.
    • Of the 81, 27 received a FQ and had no infection.
    • Of the 81, 11 received a FQ because the doctor could not assess the need properly.
  • Of the 19 who received a FQ for appropriate indication, only 1 received both the correct dose and duration!

Bottom line, out of 100 patients studied who went to the E.R. and received a FQ, only 1 received, what was considered, the correct use, dose, and duration.

Despite being several years old, the findings are both shocking and ludicrous!Emergency Room

The paper states that “judgments regarding appropriateness of therapy were rendered without prior knowledge of many of the potential risk factors.

Indiscriminate use of such a power antimicrobial has led to many thousands of individuals who have experienced adverse events, many of them permanent, and has contributed to the rise of resistant bacteria.

The paper concludes “we found FQ use in the vast majority of cases to be inappropriate by established institutional guidelines. Furthermore, in patients in whom the indication for therapy was correct, the dose and duration of therapy were almost always incorrect.

As I recently wrote, the FDA has no plans to formally notify individual doctors about the recent warning labels they placed on the FQs, despite such past statistics as these.

I have heard some folks say that a few doctors here and there are starting to get the message, which is good. However, ALL doctors must get the message!

When will the FDA take its role seriously!  #FDAFail

Lautenbach E, Larosa LA, Kasbekar N, Peng HP, Maniglia RJ, Fishman NO. Fluoroquinolone Utilization in the Emergency Departments of Academic Medical Centers: Prevalence of, and Risk Factors for, Inappropriate Use. Arch Intern Med. 2003;163(5):601-605. doi:10.1001/archinte.163.5.601.



David experienced an adverse event to the the fluoroquinolone Levaquin in 2007 at age 46. Prior to, he was a healthy law enforcement official. Now, disabled with drug induced mitochondrial disease/dysfunction, he is an FQ patient safety advocate, citizen scientist, FQ researcher, author, and commentator. He has contributed to case studies and published academic papers on the FQ’s in the BMJ, European Journal of Medicine, The Journal of Community and Supportive Oncology, Oxford Academic Clinical infectious Diseases, and contributed data to many more outlets.

4 Responses

  1. Matt P says:

    My wife went to the ER August 2, 2016 and this very thing happened to her. She has not been able to walk without crutches since. The first 2 weeks she could barely get out of bed. She went in with a possibly complicated UTI, given an IV antibiotic (which we still don’t know exactly what it was) then oral Levofloxacin 500mg for 10 days. We still need to get the ER records, but assume it was Levaquin 500mg. She took the oral 500mg the same day as the ER visit and the adverse reactions started that night. I won’t go into all the details here, but 5 weeks in and after 2 more ER visits and batteries of testing she is doing better but still not walking and easily fatigued. Crazy journey and hard for our 5 year old to understand what is happening to her mommy.

  2. Harry Sophman says:

    Does not work for Fluoroquinolone Toxicity. Waste of money.

  3. Don M says:

    I am guessing the only thing CBD oil would do is help with mitigating the anxiety issue. That seems to work, but any other benefit is very questionable.

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