FQ Facts: Fluoroquinolones Are Chemotherapy
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Fluoroquinolones damage mammalian mitochondrial DNA via Topoisomerase II:
This article states “These results suggest that ciprofloxacin may be causing cytotoxicity by interfering with a mitochondrial topoisomerase II”
Quinolones and damage mammalian mitochondrial DNA:
FDA’s April 27, 2013 Pharmacovigilance Review, where the FDA notes that the mechanism for action through which fluoroquinolones induce peripheral neuropathy is mitochondrial toxicity.
Fluoroquinolones as adjunct to chemotherapy:
Fluoroquinolone based chemotherapy agents:
Antitumor Power of The Quinolone Antibiotics
Article states “quinolones having significant potency against eukaryotic Type II topoisomerases (topo II)”
Fluoroquinolones described as chemotherapy
“Late Effects” of chemotherapy