Thank you for watching this video. The following is a list of links to materials documenting the data presented in this video.
Fluoroquinolones damage mammalian mitochondrial DNA via Topoisomerase II:
http://molpharm.aspetjournals.org/content/50/5/1178.long
This article states “These results suggest that ciprofloxacin may be causing cytotoxicity by interfering with a mitochondrial topoisomerase II”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760005/
This article states “quinolones target bacterial gyrases (34) and mtDNA topoisomerases (15),”
Quinolones and damage mammalian mitochondrial DNA:
https://www.myquinstory.info/wp-content/uploads/2010/01/Castora-DNA-Synthesis-In-mam-mtDNA-1983.pdf
FDA’s April 27, 2013 Pharmacovigilance Review, where the FDA notes that the mechanism for action through which fluoroquinolones induce peripheral neuropathy is mitochondrial toxicity.
Fluoroquinolones as adjunct to chemotherapy:
http://infectagentscancer.biomedcentral.com/articles/10.1186/1750-9378-7-33
http://www.nature.com/bjc/journal/v95/n8/full/6603355a.html
https://www.ncbi.nlm.nih.gov/pubmed/10414727
Fluoroquinolone based chemotherapy agents:
http://www.sunesis.com/vosaroxin.php
Antitumor Power of The Quinolone Antibiotics
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997924/
Article states “quinolones having significant potency against eukaryotic Type II topoisomerases (topo II)”
Fluoroquinolones described as chemotherapy
http://faculty.ccbcmd.edu/courses/bio141/lecguide/unit2/control/antibio.html
http://www.ijppsjournal.com/Vol4Suppl4/4790.pdf
http://pharmaxchange.info/press/2011/05/mechanism-of-action-of-quinolones-and-fluoroquinolones/
“Late Effects” of chemotherapy
http://www.cancer.net/survivorship/long-term-side-effects-cancer-treatment
http://www.mayoclinic.org/diseases-conditions/cancer/in-depth/cancer-survivor/art-20045524
http://ww5.komen.org/BreastCancer/LongTermSideEffectsofChemotherapy.html
