Fluoroquinolone FAQ2022-03-28T14:11:26-05:00

Please note this is Frequently Asked Questions (FAQ) as opposed to Facts.  Over the years, I have been asked a lot of questions regarding Fluoroquinolone (FQ) Toxicity, going back to about 2009 when this site was created. The following is a compilation of  some of the most prevalent questions I am asked and what my answer would be in a nutshell. These answers are my opinion based on my experience, being involved in research, and a truckload of anecdotal information from individuals experiencing Fluoroquinolone Toxicity.  Again, these are my opinions and subject to change when subsequent facts change. If you are very new to Fluoroquinolone toxicity and in the throes of an adverse event I advise using caution as some of the data is heavy. Please read my disclaimer for information used on this website.  I ad to this page frequently. Updated: 03/28/22

Are The Fluoroquinolones Failed Chemotherapy Drugs?2021-05-11T10:14:11-05:00

NO. There is the false notion perpetrated by some websites and then echoed around social media that the Fluoroquinolones were failed chemotherapy drugs (as in anti-tumor or anti-cancer).   The truth is they were derivatives discovered by failed attempts to synthesize anti-malarials.  The Fluoroquinolones were never initially developed to battle cancer, period!….. But please read on.

I have written and still write about the history of the Fluoroquinolones so I will give you an extremely shortened version of the truth. In 1946, researchers C.C. Price and P.M. Roberts were experimenting with the anti-malarial chloroquine in order to seek a synthetic derivative.  One of the compounds they obtained was the compound quinolone-carboxylic acid.  It wasn’t until much later that a researcher by the name of G. Lesher working with the Sterling-Winthrop Institute, started working on various analogues of the quinolone-carboxylic acid.  One of these analogues  was nalidixic acid, the grandfather of today’s Fluoroquinolones.

Nalidixic acid emerged as a very potent anti-bacterial agent.  Never in G. Lesher’s papers does he mention their use for anti-cancer or anti-tumor agents, never! Their penchant for chemotherapeutic or anti-tumor effects were later discovered, much later, after knowledge about the Fluoroquinolones method of action was more fully understood and knowledge about DNA increased.   When quinolone antibiotics emerged on the scene, the science realm didn’t know much about DNA, especially mitochondrial DNA, and how these drugs impacted both so negatively.

It is truthful to say that they original Fluoroquinolones would have made poor anti-cancer drugs because they are not metabolically focused enough to target just certain cancer cells (but often neither is traditional chemotherapy as well), but that was not the manufacturer’s intent. However, for researchers the Fluoroquinolones do show proven anti-tumor qualities and provide a good platform (scaffold) on which to develop new ones.

Also, their method of action, via topoisomerase inhibition, is the same as certain other anti-cancer (chemotherapy) drugs.   Thus, by default, this qualifies the Fluoroquinolones as anti-cancer or chemotherapeutic agents.   These are strong agents that should never be given out haphazardly.  Also, it is true that new anti-cancer drugs are being developed from the Fluoroquinolones.  The fact is, if you have ever taken an Fluoroquinolones, you were given chemotherapy (anti-cancer), in every sense of the word.

So yes, the Fluoroquinolones are devastatingly harmful drugs.  They are chemotherapeutic agents in the truest sense of the word.  However the term used “failed chemotherapy” is used by websites to garner sensationalism.

I started warning about the re-purposing of the Fluoroquinolones as full-on anti-cancer drugs several years ago (1).  I have discussed in many articles and posts how researchers see them as a powerful scaffold on which to build many more pharmaceuticals (antibiotics, chemotherapy, and antivirals).  Researchers in 2011 said, “… quinolones an endless source of hope and enables further development of new clinically useful drugs.” (2).

Are There Any Doctors You Endorse?2022-05-30T14:35:48-05:00

No. I routinely get asked if I have heard of and/or endorse certain doctors.  Not that I have heard of all of the doctors out there, but I am aware of most of the prominent doctors who claim to able to treat Fluoroquinolone toxicity. From the really expensive ones on the east and west coasts, to some chiropractors interspersed across the U.S that advertised through Google ads, there are several ‘doctors’ who claim to treat fluoroquinolone toxicity.   Despite this: I do not endorse anyone.  

Why? I have the benefit of getting a lot of feedback from people who have patronized various doctors, both good and bad.  Despite what you may hear online or read in the news, or on their website, none of them have a real good track record when you get right down to it.  I have been told about some doctors who scrub the web of negative publicity. 

I have also been told about certain medical professionals who require that the patient sign a non-disclosure agreement refraining from negative reviews. Aaron Minc, Attorney & Founder of Minc Law who specializes in business law says doctors should refrain from including provisions in patient contracts that prohibit, restrict, or penalize patients for writing online reviews. These provisions are unlawful under the Consumer Review Fairness Act and could result in financial penalties as well as a federal court order. (1)

While it is true that doctors may get lucky from time to time when treating fluoroquinolone toxicity , especially FQAD,  when you get right down to it and analyze the specifics, none of them are really ‘curing’ Fluoroquinolone toxicity.   If not, why the positive reviews?

The answer is: low hanging fruit. 

Our friend Merriam-Webster defines Low Hanging-Fruit as the obvious or easy things that can be most readily done or dealt with in achieving success or making progress toward an objective.  This is not meant to be a derogatory reference, it just means that most of the supposedly floxed people that end up being ‘cured’ or successfully treated were done by correcting obvious or easy things.

Let me let you in on a little secret; most of these people were destined to heal either way.  Not to brag, but even I, not being a medical doctor, could probably make an armchair diagnosis about some of the more obvious symptomatology and be right.  I believe that these are the cases that are being helped the most and then touted by certain doctors.    

In 15 years, I have yet to be contacted by someone with chronic Fluoroquinolone toxicity or FQAD who has been cured or even greatly helped by a doctor.   I realize that this is subjective and doesn’t include doctors who have provided symptom relief.  But truthfully, most patients walk away not helped, but definitely poorer.

I am not being negative or cynical and there are some good doctors out there that are trying their level best to help people who are suffering.  I am just telling the truth as I see it.  Generally for every person who tells me a doctor is good at treating Fluoroquinolone toxicity, I get three or four that tell me that same doctor is not good.  If a doctor ever comes on the horizon who actually is helping people recover from FQAD, has a great track record, and is not further victimizing people, I will shout their name from the rooftops.  Until then, I endorse no one. 

Are There Any Private Research Non-profits That You Support?2021-02-13T12:47:08-05:00

No. Despite what you may hear, and separate from the limited academic university research, in my opinion there are no private non-profits that are currently working on the FQ problem from a scientific research standpoint that will produce tangible, real world results.  Oh yes, there are a few smaller non-profits (at least two that I know of) and one of them is, in my opinion, wasting precious money from an already limited supply researching outcomes that will not lead to treatments.  It is my opinion that they are too pigeonholed or myopic in their focus and dominated by strong self-interests that do not work well with others. Seriously, I am not trying to be negative, but pragmatic and practical.  

If you are interested in donating to Fluoroquinolone Toxicity Research or Helping Floxed Individuals, click here.   I have created a page that provides options for those that want to help out. 

The FQ molecule is complex in its ability to damage, especially the DNA. For us as a community, even proving the fact that FQ’s cause DNA damage isn’t good enough. It is essential to be able to identify ‘what’ metabolic systems are breaking down in each individual person, as the trajectory each floxed person takes is different after the initial insult. Thus is the inherent wickedness in DNA damage; different combinations of metabolic systems breakdown in each person. The only way to cast a wide enough net in this heterogeneous mix and elucidate treatments is through science such as metabolomics.

On a nation-wide scope, I support the Open Medicine Foundation. Like I have said all along, the contributions made by the ME/CFS community will one day benefit us all. I have no doubt that in the future the first testing protocol using metabolomics to identify “what” is breaking in each individual will come to the flox community from the ME/CFS community based on their ability to work together, raise money, and identify and fund researchers. There are many, many closet floxies in the ME/CFS community and many don’t even know it.   The Open Medicine Foundation is researching as we speak how to elucidate treatments for ME/CFS through metabolomics and their research will directly benefit us. 


Are there any publications that can help me with this situation?2020-10-31T11:35:10-05:00

No and…..no. That is unless you want to look through existing published research on the Fluoroquinolones which is both disparate and spread far afield. There are ebooks on the internet that are nothing more than a compilation of community acquired knowledge that is publicly available in the file sections of some of the bigger Facebook groups.  Basically, most books you find on Fluoroquinolones toxicity are nothing more than guides on how to optimize certain vitamins levels in your body, eat healthy, and live a healthy lifestyle.  Sure, optimizing your magnesium levels and bringing up your vitamin D levels usually will make most people feel good.  If it cures you then you were not floxed!  The nuts and bolts of floxing involves things like mitochondrial damage and other complex and detailed metabolic issues.  These things cannot often be sorted out in several page ebook that you pay $19.95 or $39.95. 

There are no ‘cures’ or ‘solutions’ or ‘treatments’, so books labeled as such should be looked upon as highly suspect, especially if you do not have the money to afford the purchase. I do not want to see anyone victimized. Chances of your learning anything groundbreaking is pretty slim.

My best advice is to read certain websites, like this and certain Facebook groups.

There are good books that describe the travesty of FQ Toxicity, in terms of it being a international crisis, such as written by the late, well respected, Dr. Jay Cohen.

If you are new to this plight, please avoid reading the “Flox Report”, which is available in my files section (no I am not trying to subliminally get you to read it!).  Although it does a good job of describing symptomatology and some mechanisms, other areas such as timelines are outdated and can cause unnecessary fear and worry for those not experienced.

Also, it is very important to note that what works for one person, can be a disaster for someone else.  This has been exampled time and time again.

Can 23andMe and Other Genetic Mapping Services Detect FQ Damage?2020-10-30T11:26:42-05:00

No. Your genetics are fixed and unchanging so 23andme or similar sampling cannot elucidate any damage to your genome. 23andme does not sample the entire genome only around 600,000 or so SNP’s which cover what they consider the most active parts of the genome. In other words, the sections that they believe gives them the biggest bang for their buck.

Having said that, 23andme testing is helpful for comparing current symptoms with what is shown in your data. It can give you insights as to ‘why’ you are responding a certain way. Remember genetics are probabilities not actualities. For instance, it is helpful to know if you are homozygous for MTHFR or other SNP’s such as CYP that can effect how you metabolize drugs, which can effect your healing after being floxed. Remember, jut just because it is listed in the genes does not mean you will respond that way.

There was some erroneous information floating around from a supposed credible source in the floxing community that services such as 23andme could detect DNA damage.  Occasionally this rumor will ‘make the rounds’ so to speak.

I have had my genome sequenced by a couple different companies, 23andme included. I have learned some amazing insights about myself, including why I have some of my symptoms today post floxing. Even though I recommend the floxies eventually patronize a service such as 23andme if possible, I have one word of caution, with these genetic services it is easy to get caught going down a ‘rabbit hole’, as there is still so much more unknown about the human genome that is known. None the less, they can bring about some fascinating insights, some of which could help you learn how to help yourself heal.

Again, these services are good for learning more about yourself but they cannot identify nor quantify any damage to the nuclear DNA.

Can I Be Re-floxed by Other Drugs or Foods?2022-05-25T14:47:22-05:00

Obviously, if you take another drug from the family of the fluoroquinolones after you have already had an adverse event to a fluoroquinolone, there is a good chance that you could have another adverse event that could be worse than the initial one.

There are some other pharmaceuticals that are close cousins in their chemical makeup and whose side effect profiles are similar that could pose a cross adverse event susceptibility.  Those pharmaceuticals are from anti-malarial family.  For me information read: Cumulative Toxicity of the Fluoroquinolones

The claims of being re-floxed from foods and other substances are questionable at best, and may accusations are subjects of controversy and internet hearsay.  The reason for this is simply well-meaning people attempting to explain something that they do not fully understand. Before that statement upsets your apple cart, let me explain.

The amount of biochemical pathways in the body is astronomical.  If you doubt me, please follow this link and have a quick peek.  http://biochemical-pathways.com/#/map/1

When you have an adverse event to the fluoroquinolones your homeostasis becomes thrown off and many biochemical pathways become unstable or outright damaged.  When this happens seemingly innocuous substances can easily unbalance these already disrupted pathways causing a return of unpleasant symptoms.

These innocuous substances could have been foods that you easily tolerated before, or it could be something more substantial such as another pharmaceutical.  What is happening is that these substances are putting pressure on a damaged or strained biochemical pathway causing a return of symptoms.

Often people attribute these flares as eating foods, or drinking water containing FQ’s or taking a substance that is causing the FQ to be released from the adipose tissue (fat).   Due to the parts per million distribution factors or an understanding of partially decomposed FQ molecules in adipose tissues, I have never seen any hard evidence (research) support these attributions.

Before you get upset and start telling me that you have talked to people who have been refloxed from food just remember one thing.  Over the last decade or so, I have talked to literally hundreds of folks.  I know one guy who ate at KFC, five days a week after he recovered from floxing or another lady who ate farmed salmon at least twice a week, etc…

Now don’t misunderstand me, these sensitivities are not in your head. Due to the extensive damage that FQ’s can cause, it is entirely possible to become sensitive to other drugs (through inhibition or damage to the CYP system in the liver) or  foods (through damage to the gut), even chocolate 🙁 .  So, yes, it is entirely possible to have other substances cause a negative reaction or symptom in the body, however these sensitivities are generally very unique to the individual.

Keep in mind that in medicine, all treatments are probabilistic.  This simply means that each individual will have treatments to which they do not respond even though others do. In general, it seems Floxies seem to tolerate supplements and natural treatments at a much higher proportion than pharmaceuticals, but pharmaceuticals are more powerful so their effects are felt easier.   It seems that those who suffer neurological issues post floxing develop idiosyncratic reactions to previously tolerated medications and supplements more that those having only musculoskeletal adverse events.

Am I saying that there are no FQ residues in our foods?  No, not at all.  There are all kinds of drug residues in our current food chain, unfortunately.  Just use common sense and do what you believe to be the best for your body.

I do believe that a person should try to be as wholesome (avoiding over processed animal meat and foods that could have higher FQ tissue concentrations) and eat pure as you can and avoid many of the synthetic substances that are in our diets today.  However, too much hearsay and fear about the consumption of food causes undue stress and worry in some individuals, which in itself can become a problem.  I have actually seen that far more than actual claims of refloxing from food.

Remember, when very sensitive, the slightest thing can throw us off and it can be quite different for each person.

Please read my other FAQ on “Why do we have cycles?”

Can You Tell Who is Going to Have an Adverse Event to The FQ’s?2020-10-30T11:34:53-05:00

No.  And that is what makes these drugs so insidious.  There is still not enough known about ‘how’ the Fluoroquinolones damage the human body to develop a test to determine who will have an adverse event. There are some strong suggestions that some genes may play a role in an adverse event such as certain CYP polymorphisms which effect drug metabolism, but so far none have proven universal enough to developing an accurate test.

Having said that, I have made some loose correlations from data over the years linking certain groups of individuals to a higher prevalence of an adverse event from Fluoroquinolones.  You can view this data here.  Please note that these lists are not all inclusive.  

Do The Fluoroquinolones Remain In the Body?2020-10-12T09:10:51-05:00

This is a subject of intense debate.  Before I give you the yes and no answer, let’s review one point:

It is not necessary for the drug to remain in the body to wreak long term havoc.  Let me repeat, “It is not necessary for the drug to remain in the body to wreak long term havoc.”

Before some of you with preconceived notions get upset, let’s look at a few logical points to back up this assertion.  If you have been consuming alcohol and/or smoking, the effects of either drinking or smoking permanently stop 2 to 3 days after you quit using them, right? Of course they don’t.  There are many individuals who had to deal with the consequences of smoking or drinking years after stopping.

Now I am not trying to be sarcastic, uncaring or rude. I just want make a point that substances can have a strong, long lasting consequences.  Because of this, there can be no expectation your side effects or adverse events will go away when discontinuing the medication.

Let’s look at another point regarding mitochondrial damage.  The analogy is the snowball rolling down the hill.  In some people, when you damage the mitochondria it is akin to starting a smallSnowball Effect snowball rolling down from the top of a large hill.  Initially the snowball is almost unnoticeable.  But as the snowball rolls downhill it gets larger and picks up speed, becoming more damaging as it proceeds. When drug toxicity damages mitochondria the damage is not immediately observed. Many times people believe the have recovered or never had an adverse event in the first place. Since mitochondria turn over slowly in many tissues, time is required for the amount of mitochondrial machinery and the ability to synthesize ATP fall below a pathogenic threshold value.

Because limited space I will not go into all the ways FQs can damage your body, but one more avenue they can damage your body and leave, and that is through epigenetic influence, or the turning ‘On’ or ‘Off’ of genes that control disease processes.  In this scenario the FQ’s basically switch ‘On’ a process that becomes a problem ‘down the road’, then they leave.

So no, I personally, do not believe that the intact molecule remains in the body.  I believe it does its damage and it leaves.

Additionally, I am not aware of any academic or private documented research that proves the intact molecule remains in the body.

But there’s more…

As you probably know by now, nothing is simple when it comes to the FQ’s. I believe that in some people the FQ molecule breaks apart and various metabolites remain.  These metabolites can remain in adipose (fat) tissue. These metabolites have the ability to join with other metabolites from concomitant substances (other drugs such as NSAIDS) to form toxic metabolites.  This theory is purely anecdotal but is pretty sound based on input from over a decade of interactions.  The FQ molecule is complex and we know of some of the metabolites it can break down into but, again, there is no documented research that elucidates all the metabolites the FQ molecule can break down into.  There are many variables so I do not know if that will ever bee accomplished. We do know from research that  FQ metabolites can adduct to cellular micro and macro structures causing problems with various structures in the cell such a lysosomes or DNA.

Does adding Fluorine make the Quinolones toxic?2023-04-23T13:56:44-05:00

No and Yes!  How is that for an answer?  A somewhat nasty toxicity profile can be traced back through the quinolineconfused pharmacophore all the way back to the cinchona tree (the natural source of the alkaloid compound that the synthetic quinolones had as an inspiration).

The first medical case report of a short-term quinolone induced syndrome from a non-fluorinated quinolone was reported in the year 1972, before fluorinated fluoroquinolones were invented. The report “Nalidixic acid arthralgia” detailed a case of diffuse severe arthralgia, difficulty focusing, photophobia, and CNS disturbances of delirium and hallucinations. Nalidixic acid (trade name NegGram) was the basis for quinolone and fluoroquinolone antibiotics and technically was called a naphthyridine due to the extra nitrogen atom at position eight on the quinolone nucleus, similar to future fluoroquinolones enoxacin, gemifloxacin, tosufloxacin, and trovafloxacin.

Why is fluorine added? Fluorine greatly increases a molecule’s lipophilicity. Incorporating fluorines increases fat solubility, improving its partitioning into membranes and hence increasing bioavailability. In addition fluorine can also aid hydrophobic interactions between the drug and binding sites on receptors or enzymes.

It could be argued that with the addition of fluorine, the subsequent metabolites produced by the FQ molecule’s metabolization, caused an exponential increase in the ability for toxicity.  So, I concede that the fluorine addition probably made a pharmaceutical that had a penchant for toxicity much worse. 

Given that, is it just as simple as detoxing fluoride from our bodies?  Unfortunately no.

Bottom line, the quinolones had the capability to be toxic before the addition of fluorine but gained the ability to be super toxic after the addition of fluorine.

Is there a cure or treatment for Fluoroquinolone toxicity?2023-04-23T14:01:16-05:00

No, at this time there is no cure. And there is no reliable universal treatment program either.  Please read on….

In order for that to change there needs to be in-depth academic research, and in order for in-depth research to occur we need greater acknowledgement from the FDA and other medical peer groups. Right now, Fluoroquinolone Toxicity, despite acknowledgement from the FDA, is still treated as highly suspect by most medical doctors.   Some doctors believe it is about as credible as the Bermuda Triangle or Bigfoot and relegate it to the lunatic fringe. This is, in my opinion, one of the greatest aspect of the travesty of the Fluoroquinolone Toxicity (FQAD).  Doctors either dismiss the patient or attribute the patient’s symptoms to something else.  Many people come into this community expecting greater acknowledgement from doctors, the FDA, and expecting the ability to find a cure or reliable treatment.

On a positive note, prior to COVID, there was a change slowly starting to take place as more doctors (not all by any stretch of the imagination) and the FDA are slowly starting to recognize that there is a problem.

I have been at this going on 14 years now and have talked to hundreds of FQ victims and have had direct and indirect interactions with many, many more.   I have worked with researchers, been published on FQ’s, met with the FDA, and have even been been foolhardy to pay out of the pocket in the past for expensive health consultants. I don’t say this to toot my own horn but to tell you that this ain’t my first rodeo. I have watched groups of people take three paths in an attempt to heal; #1, do nothing, #2 pursue alternative healing methods either through naturopaths, holistic healers, etc…, #3 rely on traditional doctors and traditional medicine.  With the slight exception that the group choosing to follow path #3 has seems to have a slightly worse outcome, no path has resulted in demonstrable healing over the other.  There are many opinions, but keep this fact in mind, if there was a universal cure you would have heard about it and there would not be thousands upon thousands of individuals in various health forums and Facebook groups supporting each other and looking for cures and seeking to make a change in our medical system.  All these people would be healing and moving on with their lives.

The reason that there currently is no cure lies in the complexity of the damage caused by FQ toxicity. Most of the damage is genetic in origin and it creates a syndrome that can be so widespread that most doctors consider it preposterous. Like I said earlier, in many medical circles, FQ Toxicity is about as accepted as Bigfoot or the Bermuda triangle, and attempting to insist that the Fluoroquinolones caused your symptoms will get you relegated to the lunatic fringe by many medical practitioners. 

If someone tells you they have found a ‘cure’ for FQ toxicity, they are trying to sell something.  Period.  There are doctors claiming to ‘cure’ or treat FQ Toxicity with very, and I mean mean very, expensive treatments.  Despite the extravagant price tags and a handful of claims of success, if they were truly successful everyone would be flocking to them and you would hear stories of hundreds of cures.  Please be careful as there are those who will seek to victimize those in the FQ community, or anyone who is experiencing chronic health issues, by charging for ongoing frivolous consultations, very expensive supplements, proprietary stem cell treatments and I.V’s, and or unconventional medical equipment.  I have written a cautionary tale about Internet Health Consultants.  Most medical systems, including those practiced by well-meaning naturopaths and homeopaths, follow paradigms.  Experience has shown that floxing falls outside these paradigms because you are looking at damaged caused by a synthetic, DNA altering, chemotherapeutic substance.

Now, by this point in this FAQ you may be getting bummed out.  Seriously, I am not trying to be a Debbie Downer.  It is not to say that people do not heal, some do, some even recover quite successfully.  Recovery is dependent of many factors such as age, cumulative dosage limits, genetics, environment, and more. Even so, there have been individuals who have found relief from various symptoms by finding solutions tailored to their body but, as with most helpful substances or routines, they are tailored to the individual.  What helps heal one person can do tremendous damage to someone else.  At this time, time plus very clean living is the best healer for many.  If you find something that you believe helps you, great.  If it made a big difference let me know about it.  Just be careful recommending it to someone else.

Is there a single reason why people have adverse events to the Fluoroquinolones?2020-10-30T11:29:36-05:00

No… not really. It really all boils down several reasons or a combination of factors. In some individuals we see poor metabolization of the Fluoroquinolone molecule. This is probably due to genetic CYP phenotypes COMBINED with other systemic variables and concomitant substances. Once they metabolize improperly and depending how much of the dosage breaks down into various metabolizes, you are heading for an adverse event.  At that point it depends on the type of metabolites that are left over from the original molecule, quantity of the left over metabolites, and probably systemic variables such as cellular PH, trace elements (metals), and a host of factors.

It would seem that CYP polymorphisms could play a role, in part especially in shotgun reactions or adverse events that come on fairly quickly. Cytochrome P450 (CYPs) are the major enzymes involved in drug metabolism, accounting for about 75% of the total metabolism. These pathways are highly polymorphic or heterogeneous (variable) in humans, plus there are so many other drugs and naturally occurring compounds that influence  CYP activity as well.  Because of this, trying to quantify their involvement in a Fluoroquinolone adverse event is difficult. 

The Fluoroquinolones also display cumulative toxicity patterns.  Meaning that they have a ‘threshold,’ much like certain anti-cancer chemotherapy.  When this threshold is crossed an adverse event ensues.  Other drugs, such as certain anti-malarials, can contribute to this cumulative toxicity. See the article: Cumulative Toxicity of the Fluoroquinolones

Due to the heavy epigenetic quality of the Fluoroquinolones the molecule can metabolize normally and still ‘switch on’ latent genetic predispositions that become pathogenic over time.

Some things that have been ruled out as universally causing floxing are Blood Type, MTHFR, G6PD.*

* These issues could very well play an important role in the severity, type, and length of some symptoms in certain individuals  In other words they could affect downstream issues.

Is there a test for Fluoroquinolone Toxicity?2022-03-28T14:10:03-05:00

Fluoroquinolone toxicity creates a syndrome. Fluoroquinolone Toxicity (FQAD) is a novel syndrome that mimics many different disease processes, such as MS, Fibromyalgia, Chronic Fatigue Syndrome, etc… Yet, even though it may mimic these other pathologies, it also sets itself apart in many areas. Many sufferers experience wider ranging and more intense symptoms than many who experience the organic disease processes.

Due to lack of research and guidance form the FDA many doctors are woefully ignorant to Fluoroquinolone toxicity and the syndrome that it causes. There needs to be intensive academic research that defines the causal mechanisms and damages that manifest after an adverse event is experienced.

The Fluoroquinolones can and do damage and exert pressure in several different ways. First, they have the ability to cause direct DNA damage. Second, they have the ability to exert tremendous epigenetic pressure thereby ‘switching’ on or off’ genes and creating a pathogenic process. Third, they set the state for extreme states of oxidative stress that damages cell structures and influences gene selection. Fourth, they can directly damage delicate cellular structures such as lysosomes, cell membranes, and external and internal cellular proteins responsible for cellular communication and more. These are just a few of the more prevalent ways that Fluoroquinolones do damage to the human body.

I have seen genetic results from literally dozens of floxed folks, and at this time it would appear that there is no clear genetic predispositions to floxing, including MTHFR.  Genetic tests from severely floxed individuals has shown no mutually shared genetic markers.   There is some indications that certain CYP polymorphisms may lead to more extensive metabolization in some individuals and this clue needs further research.

Stem Cell Therapy, What Is Your Take?2023-04-23T14:04:00-05:00

First let me throw in the caveat that I find new healing modalities, such as stem cell treatments, quite fascinating so I don’t want to have my opinion confused as a stem cell hit piece.   I am looking at the totality of the information and forming my opinion.

Right now, stem cell research is in its infancy.  It does seem to hold promise for future systemic treatments and it has proven itself successful for certain localized treatments. I, however, have not talked to anyone with genuine FQAD that has been systemically helped by stem cells, yet.    If you have been helped please contact me as I would be interested in hearing from someone who was chronically suffering and had their lives turned around by stem cells.

For me the unfortunate reality is this; I have heard from a handful of genuine severely floxed folks who have gotten much worse after stem cell therapy.  A couple of folks initially had what they thought was an overall systemic benefit, only to see that perceived benefit disappear and in some their chronic symptoms got much worse.  Although I don’t pretend to understand the mechanism of temporary improvement (possibly placebo), I can make several educated guesses as to why it would be negative from a genetic basis.

To be fair, I have talked to some folks who have had stem cells injected locally, such as a knee, shoulder, or spine, to solve localized problems that have had some improvement, but no systemic body-wide ‘reset’ or great systemic improvement has been reported to me. 

There is a lot of rumor and hearsay of folks claiming miracle cures with Stem cells, and when I have looked into some of these cases by further checking into the veracity of their claims, the actual facts surrounding their recovery was dubious at the best,  as was their ‘perceived’ level of floxing.

Stem cell treatments have cropped up all over the place, about as much as places selling miracle CBD oil.  And because of this it is hard to separate truth from fiction. There are all kinds of practitioners claiming to be ‘experts’ in an area of stem cells and genetics.  These are areas that even those with advanced PhD’s do not fully understand.  Because of this, do you expect the local chiropractor to be a stem cell expert?   There are the occasional nightmare reports from these stem cell clinics, such as this example here

One popular floxed stem cell treatment professional, who I consider was initially mildly floxed (if even floxed at all), treats patients with stem cells charging up to to $10K as day!  The person has excellent reviews online.  Behind the scenes there is a much different uglier truth.  I have heard from floxed critics, both patients and a fellow MD and researcher, who paint a much different picture. The MD says that they have collected stories of very bad outcome from stem cells.  The patients have told me stories of how this professional has ‘gone after’ aggressively to shut down any criticism or squelch negative opinion.

To compound the confusion, things such as healing and suffering are subjective.  For instance, a person who receives stem cells and gets improvement in their pain, but is still unable to walk, might look at their stem cell venture as a success.  Yet, another person might consider it a complete failure.  Stem cells are different, depending on their locale in the body so promises of system improvements can be misleading.

By reading my website you will find that I am in no way a fan of the FDA.  Despite this, they have issued warnings on stem cell treatments and some of their concerns are valid.   We can’t throw the baby out with the bath water.

For me, success is weighed only in a substantial alleviation of floxing symptoms allowing a person a complete return to a functional lifestyle. 

Then there is the cost factor.  Stem cell treatment is expensive, very expensive.  I have also corresponded with some that have come away feeling victimized after spending $25,000 for stem cells treatment that did not produce viable results.  Some individuals have mortgaged their homes and put their families in financial hardship just to get stem cell treatments. 

Listen, I do get it and I am not without compassion because I know people are scared, in pain, and suffering. If I knew for a fact that stem cells would help me, I would raise money and try them myself (non-embryonic). However, I have heard it time and time again, people get desperate and look for help and they want it right now. They don’t want to hear anything negative from me or anyone else, they just want to get better. Believe me, I, and many, many others have been there.  The bad news is that people are often vulnerable during these times and can easily be taken advantage of, and in the area of stem cells it would be easy to be taken advantage of.  My advice is to read this article from the International Society for Stem Cell Research entitled  Nine Things To Know About Stem Cell Treatments.

If you decide to pursue this avenue, please research thoroughly and use extreme caution.

Bottom line, as of this time, there are no stem cell clinics that I endorse, and even if I had a lot of money to spend on stem cell treatments, I would personally not risk stem cell treatment on myself.  

TIPS for the Newly Floxed2023-09-27T11:21:14-05:00

More than likely this is a very trying time and highly emotional time for you.  The amount of information on (Fluoroquinolone) FQ toxicity is overwhelming once you start digging through it,  so please use caution.

Keep a few things in mind.

First, statistically your chances of a functional recovery are pretty good, especially if you are young. 


Second, when reading through forums and Facebook groups you will encounter a lot of perceived negativity. The reason for this is that people do feel horrible, both physically and emotionally, and they come online and express their feelings.  They need a place to outlet their frustration and to find others who are going through the same thing. People need safe places to vent frustration and discuss their physical and emotional problems.  Because of this you will find various people in various emotional and physical stages, do not apply this to you.

Third, and possibly the most important, it is very, very, very important to note that what works for one person, can be an absolute disaster for someone else.  This has been exampled in our community time and time again.  Do not go out and buy a boatload of supplements (unless you are under the care of a qualified practitioner) and start mega dosing things that you hear are helping others.  Desperation drives people to throw common sense out the window. If you do intend on trying something, research, research, research.  Please.

Fourth, be kind to yourself.  I know that you are desperate.  Do not starting reading things such as the ‘flox report’, which can scare the ‘Holy Living Crap’ out of some new folks.  Although the book has some good technical and symptomatology data listed in it, it is also becoming quite outdated and thus inaccurate some areas.

Fifth, absolute uncertainty is one of the hardest things created by FQ toxicity.  This will be just as much a psychological battle as a physical battle. FQ adverse events are often based on your uniqueness as a human being (strengths and weaknesses). Despite what you read or hear, there are no set patterns or time lines.  Anyone that tells you that there are, are full of the proverbial ‘horse hockey’.  Symptoms can be similar, but in all reality, no two adverse events are exactly alike nor do they have the same time-lines.  Too many times I have heard people say “you will be over that by six month”s or “that will go away soon”. It is human nature for us to want to extrapolate someone else’s time-line or symptoms onto ourselves, DO NOT DO THIS!  This is terribly unfair to you and can cause undue pain and hardship.  And for gosh sakes, do not accept recovery advice from someone who has been at this only six months!

Sixth, there are plenty of places online to find like minded individuals who will help you share your burdens, but again you will encounter people in varying stages of severity.

Seventh, despite research and admissions from the FDA, expect denial from many medical professionals.  Its frustrating to say the least.

Eighth, there are no doctors, consultants, or bloggers who can ‘cure’ FQ toxicity.  Zero, zilch, nada. If they say they can, they are trying to sell you something and it is usually very expensive. Again, THEY ARE TRYING TO SELL YOU SOMETHING EXPENSIVE. There is no secret cure being safeguarded by a monk on a mountaintop in Tibet, or by a chiropractor practicing genetics, or by a self-proclaimed MD guru in California.   FQ toxicity is a systemic multi-faceted dilemma that is best treated symptomatically and by providing the necessary healthy support for your body to heal.   However, just because there are no experts on FQ Toxicity does not mean that you should not have serious health symptoms checked out and it doesn’t mean you won’t heal.

Ninth, unless you are over two years (an arbitrary point) or maybe longer in your struggle, never say never, and even then things can change drastically for the better or worse.  Many people contact me who have been impacted less than six months and believe they are crippled for life.  Floxing is fluid, changing, and dynamic.

Tenth, If you are reading this then you obviously found your way to my website.  My website can be scary to newly floxed individuals.  The reason for this is because this site caters to those who are chronically floxed.  Many of the individuals are ‘lifers’ or those who have been dealing with this for a long time.  Yes, there are thing you can learn while traversing these pages but please keep this in mind.

Finally, for those new to this plight, be prepared to face challenges and losses, including friends, family, career, and even dreams. Despite it all, remember that no matter what, you are important and your perspective on the world is so valuable. We are pioneers on a journey we didn’t choose. Take the advice of a counselor who deals with chronic and complex illnesses: “Go where the current takes you.” If needed, find a counselor who understands your situation, as friends and family may not have the practical skills or emotional ability to provide adequate support.

Please read My Quin Story’s What Helps page.  It is chocked full of information gleaned from the floxie community.  The data is free of charge 🙂

What Causes A Delayed Adverse Event?2020-09-30T10:29:23-05:00

Delayed adverse events to Fluoroquinolones (FQs), although prevalent, are complex to say the least.  However if we look at how drugs damage the mitochondria we can get a good idea how this process works, especially antibiotics.

In the book “Drug Induced Mitochondrial Dysfunction”(2008 Wiley) they discuss antibiotic mitochondrial toxicity. In the book it states that mitochondrial protein synthesis is more closely related to bacterial endosymbiont than cytoplasmic protein synthesis. “As a result, antibiotics that bind to the bacterial ribosome and target bacterial protein synthesis may also bind to the mitochondrial ribosome and inhibit mitochondrial protein synthesis.”

Bottom line:  Many drugs were developed before our knowledge of mitochondria became more robust.  Because of this, drugs were not tested for their ability to be mitochondrially toxic.  The quinolones (fluoroquinolones) are one of those drugs.  Even today with out advanced medical technology, knowledge of mitochondria and how they are affected by drugs is lagging way behind.  Most doctors are unaware, and many drugs are not tested for their penchant to harm mitochondria.  The quinolone family has fallen through the cracks.  Even though over half of the developed quinolones have been removed from the market because of the penchant to ‘kill’ by damaging mitochondria, the remaining one are believed to be safe because they drugs can separate cause and effect.   How do they do this?   Read on… 

Toxicity caused by inhibition of mitochondrial protein synthesis is not immediately observed. Mitochondria turn over slowly in many tissues. Depending on the degree of inhibition, time is required for the amount of mitochondrial machinery and the ability to synthesize ATP fall below a pathogenic threshold value.” (DIMD; page 465) This delayed reaction can make connecting the adverse symptoms to an environmental exposure (like a medication or chemical) very difficult as it happens slowly, over time, as mitochondrial function falls below a critical threshold and the individual then becomes symptomatic.

In a nutshell, certain antibiotics such as fluoroquinolones, damage the mitochondria. Because mitochondria turn over slowly in many tissues it takes some time for the damages to become evident.  It is only after they reach a critical point (the ability to synthesize ATP fall below a pathogenic threshold), does the damage become evident.

The amount, speed, severity, and location of the damage in the body depends on many factors, such as how much initial toxicity was present, health of the person at the time of the initial onslaught, and their genetic makeup, to name a few.

What Fluoroquinolone Toxicity is NOT….2023-08-13T09:55:01-05:00

Fluoroquinolone Toxicity…

  • is not Magnesium deficiency.   There are theories that magnesium levels can play a role in the precipitation of an adverse event to the FQ’s.  It is also true  that FQ’s can leach magnesium.  However, low magnesium is not floxing.  If after floxing, you can ‘cure’ yourself or find a solution to your problems with magnesium then your symptoms were caused by low magnesium, NOT FQ Toxicity.  Also, it is possible that normalizing magnesium post floxing can help alleviate some negative symptoms.     

  • is not Vitamin D deficiency.   Vitamin D is a wonderful vitamin that does many amazing things in the body.  Being low on vitamin D can cause many unpleasant symptoms including pain. If after floxing, you can ‘cure’ yourself or find a solution to your problems by normalizing vitamin ‘D’ levels then your symptoms were caused by low vitamin D, NOT FQ Toxicity.  Again,  it is possible that normalizing vitamin D levels post floxing can help alleviate some negative symptoms.     

  • is not MTHFR.  According to Dr. Ben Lynch, probably the foremost expert on MTHFR mutations, the rate of one MTHFR mutation in the standard population is a whopping 50% and the likelihood of having 2 copies is between 10% and 20%.  Those of Italian and Mexican ancestry can have a much larger rate of MTHFR mutations. Having said that, over the last five years many floxed individuals have had their DNA sequenced.  When we did an analysis several years ago, it was found that the FQ community had a representation of MTHFR mutations on par with the general population.  This would see to rule out MTHFR as the ‘sole’ cause of Fluoroquinolone Toxicity. It is true that after floxing having the mutations for MTHFR can make your adverse event symptoms much more unpleasant.      

  • is not G6PD.  G6PD deficiency is a genetic disorder that most often affects males. It happens when the body doesn’t have enough of an enzyme called glucose-6-phosphate dehydrogenase (G6PD). G6PD helps red blood cells work. It also protects them from substances in the blood that could harm them.  Without enough G6PD to protect them, the red blood cells break apart in a process called hemolysis. When many red blood cells are destroyed, a person can develop hemolytic anemia causing dizziness, and a myriad of other symptoms.  It is true that the Fluoroquinolones can trigger G6PD type symptoms and probably should never be taken by those with this genetic mutation but many doctors are not familiar with this deficiency.  However, like MTHFR, the rate of G6PD has not found not to be consistent in the Fluoroquinolone community.  I will concede that there are many genes in the G6PD spectrum, but overall there are there are individuals who in the community that do not have this mutation and who are severely floxed, ruling out G6PD being a risk factor.  

  • is not caused by Flouride or Flourine. The first medical case report of a short-term quinolone induced syndrome from a non-fluorinated quinolone was reported in the year 1972, before fluorinated fluoroquinolones were developed. It could be successfully argued that with the addition of fluorine, the subsequent metabolites produced by the Fluoroquinolone’s molecule metabolization caused an exponential increase in the ability for toxicity. The fluorine addition made a pharmaceutical that had a penchant for toxicity much worse. Bottom line, the quinolones had the capability to be toxic before the addition of fluorine but gained the ability to be super toxic after the addition of fluorine. Also read Does adding fluorine make the quinolones toxic?

  • is not caused by iodine deficiency. It has bene postulated that fluorinated quinolone  leach or shift iodine in the body in such a way as to cause symptoms.  Again, FQAD has its roots, before fluorinated quinolones were developed.   If this theory was the simple cause it could be easily corrected and it would have been. Unfortunately, research has shown the FQAD is far more complicated involving epigenetic pathogenic mtDNA damage. 

What happens in a Fluoroquinolone adverse event?2021-02-13T13:10:08-05:00

Take Levaquin for instance, the drug company in its application for approval stated that 87% of the drug is recovered unchanged in urine in 48 hours and approx 4% is recovered unchanged in feces, that totals to 91%. Off the remaining percentage, they found that 5% broke down into desmethyl and Various N-oxide metabolites. Those metabolites have little relevant pharmacological activity.

However overwhelming anecdotal information has taught us that in something different is happening in some people. The fluoroquinolone (FQ) molecule metabolizes improperly and there is no way of knowing ‘who’ will metabolize it incorrectly. For the layman this means that it appears the drug breaks down and is not excreted appropriately but instead breaks into pieces called metabolites. The metabolites remain in cells adversely interfering with cellular operation.

It is my opinion, that once the metabolites start circulating, especially intracellularly, it is a virtual crapshoot as to how the FQ metabolites interfere with cellular operation. It is like an endless puzzle where one clue leads to another.  The reason for this is because the FQ’s can interfere in numerous different ways with the normal operation of the cell. There are science papers showing FQ metabolites interfering with lysosomes, cellular signaling protein both internal and external, membrane integrity, and on and on.

You can endlessly speculate, and people do, about what happens in the cell, and you know what? You would probably be right about most educated guesses you made, because the possibilities as to the type of damage to the cell, once the metabolites are present, are virtually endless due to so many variables.

Because of the this, all the body systems have the ability to be affected.  In addition, the FQ’s exert tremendous epigenetic pressure on both the nuclear and mitochondrial DNA within the cell.  This can ‘switch on’ genes in combination that can lead to pathogenic (disease) processes.

For more information see: What is Floxing?

What is one of the worst things I can do?2019-11-01T13:19:20-05:00

Let me tell you a brief story… Once this young woman came to me and asked for help.  With each and every avenue of help I offered up for consideration, she instantly shot it down.  She would tell me “Well, I analyzed this person’s case or that person’s case and I am worse than them.”

Believing herself to be wise, she dug herself into a trap that I have seen time and time again; constant comparison to others that leads to assumptions of doom and gloom.   Yes, you do know your body, but you are not smart enough to predict the future.  If you can predict the future, let me know, for I have some sports teams that I would like to bet on or stocks that I would like to invest in!  Anyway, this young lady dug herself into a pessimistic trap that was eventually beyond the reach of anyone.  The ironic part is that she constantly reached out for help and then would tell each person why she could not be helped.  It became a vicious self-defeating cycle.

Some of the absolute worst offenders are those who are floxed ‘intellectuals.’ It is not uncommon for some of them to think themselves into a quagmire of despair.   Like everything else, pain, suffering, and quality of life are hard to quantify and measure.  They are relative to the point of measurement and that point is variable per person and situation. It takes professionals years of training and experience and even then, gauging suffering is tentative at best.

Here is what I know.  Predicting your floxing outcome is like making a prediction about the end of the world: The minute you make it, it will probably get proved wrong.

Let me finish this section with one last small story.  There was this middle-aged woman who became floxed.  Initially, like so many others experiencing a ‘shotgun’ style reaction, her life was in absolute turmoil.  I kept telling her that in the first couple of years there will be many ups and downs and at times you will feel like you are dying, but nothing with the FQ’s is set in stone.  Yes, one day you can feel like dying and the next you could start healing. But alas, every time I offered a suggestion, she countered with extreme negativity.  Responding to her was an exercise in futility and it got to the point that she would get mad at me if I did not answer her pleas in a timely fashion.

One day I saw her posting on Facebook that she was healing.  She was going for long bike rides and started living life again.  Just few months earlier, she was contemplating suicide because life was so miserable.  She still has some lingering problems but she alive and living a life worth living. Please never say never!

Why are so many body systems affected?2023-04-23T14:25:12-05:00

It is my opinion that two processes create the symptoms that we see present; both mitochondrial cytopathy and cellular senescence. Both of these pathogenic processes overlap and are interrelated.

These pathogenic processes cause the vast array of symptoms that we see and encompass skeletal muscles and tendons, and dysfunctions in the nervous, visual renal, digestive and circulatory systems.  In a sense every body system can be impacted.

Undergirding these symptomatic processes is the driver of FQ induced defects in the respiratory chain inside the mitochondrion. This assembly line of protein complexes is the heart of the mitochondria and a malfunctioning chain can cause a dizzying array of symptoms.  I have postulated a theory called Mitochondrial Retrograde Signaling in FQAD, A Disease Theory. This theory explains the chronic cases. 

Some of you will understand what I just wrote and others will just go “huh?”   Seriously, I could write for pages and pages but believe me the FQ’s have the ability to insert themselves into almost every body system. That is what makes them such potent antibiotics and such a nightmarish ‘hell’ when things go awry.

Why Aren’t The Fluoroquinolones Off The Market?2020-01-04T14:22:35-05:00

The Fluoroquinolones (FQ’s) were released in the 1970s and it wasn’t until 2013 that the FDA really started sounding the warning, and even then, it was a lukewarm one. The adverse events of FQ’s are disparate and by all definitions, outrageous.  They range from permanent nerve damage, tendons spontaneously rupturing, organ failure, psychosis, and literally dozens more. Most doctors consider this broad ranging pathology preposterous and they simply can’t wrap their heads around a differential diagnosis to include the FQ’s.  Hell, most of them don’t know what to look for or how to connect the symptoms.  Because of this, they don’t get documented.  Please read Fluoroquinolones Inconvenient Truth for more information on why these damages do not get connected back to the medication. 

The FQ’s kill and damage through so many different mechanisms that it is not usually connected by doctors.

When nalidixic acid, a non-fluorinated quinolone antibiotic and the first publically available quinolone, was first released and thereafter for some time, researchers did not know about mitochondrial DNA.Snowball Effect  Because of this, how the first quinolones and the subsequent FQ’s affected the mitochondria was not on the researcher’s radar scope.  The ignorance continued on to the present day while the FQ snowball was rolling downhill ever faster and getting much larger.

Remember, there were other FQ’s, such as trovafloxacin or temifloxacin, that had “good” safety profiles, that passed all medical standards, and then removed when they started killing patients.  The damage these two FQ’s inflicted was immediate, in your face, thus they had to be dealt with.  In fact over half of all created FQ’s have been removed from the market because of safety concerns. But even more important, what about all the disease machinery that the FQ’s start in motion that kills slowly over time?  The answer to that question is both mind boggling and preposterous as well. There really is no measure for this type of insidious damage.  This style of damage is ‘off the radar scope’ of most doctors.

Since doctor’s and policy makers are ultimately responsible for whether a drug gets removed and despite patient backlash of the recent years there is still not enough loud voices raised in opposition.   Policy makers see websites such as Floxie Hope that is highly SEO’d, which means it gets a lot of Google attention, who promote stories of healing and recovery (although I have had some of these recovery stories show up at my doorstep when their recoveries did not last),  this creates the false assumption that these adverse events are all recoverable in time, or at the very least it reinforces the believe that these severe adverse events are ‘very rare.’  In other words, in my opinion, it takes away from the true tragedy that the FQ’s inflict upon society.  It reinforces the policy makers cognitive dissonance, and those who are permanently harmed for life get their stories overlooked and dismissed.

These drugs set the stage for scary long term damage. Due to damaging the genome (both nuclear and mitochondrial) this damage may not be readily apparent for weeks, months or years.   Just because the damage is not readily apparent does not mean it does not exist.

Why Can’t I Detox the Fluoroquinolones?2020-09-07T10:24:18-05:00

Occasionally I get contacted, usually from someone new to this plight, about how to detox from the Fluoroquinolones (FQ’s).   This is a complex subject that I admit is hard to make sense of given the varied amount of information that is found floating around the Internet, and unfortunately much of it based on flawed paradigms, assumptions, and beliefs.  Let’s briefly look at detoxification and, despite what you have read or heard, how most of it does not apply to FQ’s.

First of all, detoxification is unquestionably a natural process that is always going on in our bodies.  Numerous organs and systems including the liver, kidneys, lungs, lymphatic system, gastrointestinal tract, and bladder all contribute to the regular elimination of the natural metabolic byproducts of digestion, activity, and cellular regeneration.

Many aspects of our modern life can make the work of these organs much harder and given our mass produced, highly manufactured, chemically laden society, the burden placed on these organs can eventually lead to a disease process.   However many in the alternative world erroneously suggest that detoxing is possible from FQ’s.  This type of thinking presents an ignorance about how the FQ’s work in the human body.

Now, let me say that it is highly probable that, for many, the FQ’s interfere or ‘throw off’ many metabolic processes.  These disrupted metabolic processes can, for some, cause the accumulation of toxic products to occur in the body. For instance, I have seen some floxies become very chemically sensitive and it would suggest that, among other things, their metabolic systems involved in removing toxins have become impaired.   I have also seen an unusual amount of floxies become affected by or sensitive to the burden of heavy metals that have been accumulated throughout a lifetime of environmental exposure.  These things become manifest after floxing. 

For some, eating healthier, juicing, relieving chronic constipation, staying better hydrated, or some other detoxifying procedure or products (like Zeolite) provides some relief from some of the unpleasant symptoms incurred by these various malfunctioning metabolic processes and accumulation of toxins. This is all well and good but not to be a Debbie Downer it does not actually detox or remove the FQ’s or their metabolites.   It just addresses some of the downstream problems associated with FQAD. 

Remember, to stay on point, I am talking just about the removal of, or detoxing, the Fluoroquinolones or their metabolites, from the body, not other substances that they FQ’s have caused to accumulate through their damaging actions.  

Over the last decade I have talked to literally hundreds of FQ victims and have had direct and indirect interactions with many, many more.   I have extensively worked with researchers, met with the FDA (not really all that important but is sounds impressive), and even have been foolhardy to pay out of the pocket in the past for expensive health consultants during my times of desperation. I have watched groups of people take three paths in an attempt to heal; #1, do nothing, #2 pursue alternative healing methods either through naturopaths, holistic healers, etc…, #3 rely on traditional doctors and traditional medicine.  With the slight exception that the group choosing to follow path #3 has seems to have a slightly worse outcome (give or take a few percentage points), no path has resulted in greater healing over the other!  Seriously. 

If there was a form of detoxing that would work to remove the Fluoroquinolones or their metabolites from the body (if there are actually any FQ’s left in the body), everyone would know about it and everyone would use it to heal and move on with their lives.

Also, it is not necessary for the Fluoroquinolones to remain in the body for them to do damage, you can read that FAQ here

So, why does detoxing not directly affect the Fluoroquinolones?

  • FQ’s are synthetic not natural designed for deep tissue penetration.
  • FQ’s damage the body in the same fashion that chemotherapy (anti-cancer) and heavy metals damage the body (Note the FQ’s are not heavy metals). 
  • FQ’s can damage both nuclear and mitochondrial DNA.
  • FQ’s can change gene expression and start pathogenic (disease) processes.
  • FQ’s do not need to remain in the body to cause long term damage via the above genetic avenues.
  • FQ’s can damage other cellular structures besides DNA.
  • FQ’s can permanently alter the gut microbiome.
  • FQ’s can upregulate MMP’s causing long term connective tissue problems.
  • and on and on (I could literally make a list with over a hundred entries).

I will fully concede that certain detoxing regimens of procedures may help some individuals deal with or correct the unpleasant symptoms of metabolic systems that have gone awry, especially if these detox protocols are done very safely. However, caution is indicated because, conversely, for some, detoxing has proven to be dangerous and cause unwanted symptoms or harm. One thing is for certain, detoxing is not a ‘cure’ for floxing and, due to the complexities involved in floxing, cannot be universally applied to everyone as a treatment.  From the experience shared with me by many individuals who have tried detoxing,  the detoxing paradigms of many alternative medicine practitioners, who claim to be able to ‘remove’ or ‘cure’ FQAD do not apply to a synthetic DNA damaging/altering chemotherapeutic agent that should not be handed out like candy by our ignorant medical establishment.

Why do some people get better and others do not?2023-04-23T14:48:50-05:00

No one gets out completely unscathed.  The level of damage caused by the FQ’s is imperceptible in some people and very perceptible in others.   If you have an adverse event response to the Fluoroquinolones (FQs) your body took a tremendous hit from a toxic perspective. It reached critical mass. Even though some people recover and go one to live a fairly normal life, there usually is some sort of permanent cellular damage. For instance a high intensity athlete may never go back to performing at the same intensity level as before.  But before you get super upset about any of these statements keep in mind that substances that are seemly innocuous, such as hair coloring, can cause permanent cellular changes and damage.  I am not trying to downplay the seriousness of any FQ adverse event, just make sure to keep a balanced perspective.

Seemingly quite novel in the syndrome that it manifests, the only remote parallels I can draw with an adverse event to FQs is it is akin to having a very large dose of anti-tumor chemotherapy.  I have had some people criticize that example saying they know people who have had systemic chemotherapy who are in better shape than many floxies.   However, conversely, I know people who had had chemotherapy who were devastated by it, and I know people who had FQ’s who had no apparent reaction to it.

If you look at those receiving systemic chemotherapy, many, if not all, will have some lingering negative effects and reduction in some aspect of functioning. This varies from person to person just like floxing varies from person to person. Again, although novel in its form of damage, FQ damage is akin, not identical, to receiving strong chemotherapy and your ability to metabolize the dose.  Some damages from systemic chemotherapy, such a neurological and ‘late effects’, are also seen in FQ damage.  However, FQ damage, for the most part, can also manifest in ways that are much worse that standard damages seen in chemotherapy.

Again, personal metabolization variables dictate how well your body can handle the onslaught that was placed upon it by the FQ’s, so they subsequently dictate recovery timelines and levels of functioning as well. Again factors such as inherited genetic traits, age, environmental variables, all come into play, with genetics being one of the biggest players.

Why Do We Have Cycles?2020-02-16T11:29:26-05:00

Cycling after the initial adverse event has to do with homeostasis. Homeostasis is the property of a system in which variables are regulated so that internal conditions remain stable and relatively constant.  When you are healthy all of your internal conditions remain stable and you are in a state of homeostasis.  When something comes along with a severe toxic onslaught, such as the fluoroquinolones which have the ability to disrupt many body systems, your bodies’ homeostasis is thrown off. 

Various cycles in the body such as sleep, breathing, hormonal, blood sugar regulation, stress/tension, etc…all get disrupted.  When these systems are out of balance or malfunctioning you experience very unpleasant symptoms.  The more the disruption the more serious the experience.

Despite this, it is your bodies’ natural inclination to seek balance or homeostasis.  After a while, such as weeks or months, your body adjusts to its new level of functioning even if it is much worse than before.  Although healing can take place, a subsiding of symptoms does not always guarantee it.  Often times it just means that an adjustment has taken place.  Often the floxed person perceives that things have gotten better when in fact the body is now living on a precarious ‘edge’ that can easily become unbalanced.
Knife Edge

Think of your health as now balancing on a knife edge as opposed to a wide solid platform.  Before it used to take a lot of disruption to throw you off balance.  Now that you are balancing on a knife edge, it takes very little pressure to throw you off balance.

Once you are balancing on this new edge, little stressors that are placed upon the system such as physical exertion, eating a new food, exposure to a new chemical, etc… can throw you off. What causes you to be ‘thrown off’ your edge is very different from person to person as well as intensity.

Many people call this ‘re-floxing’, when in fact it is nothing more than the bodies’ homeostasis becoming unbalanced again.

If cycling becomes farther and farther apart with less intensity, it is a good sign that some healing is taking place and the foundation on which your homeostasis is conditional upon is more stable.  Keep in mind that people cycle differently.  Some individuals experience severe cycling while others experience mild cycles.

This cycling can be, and often is, very unnerving for the floxed person causing depression and psychological stress.   Often times they think the worst is behind them.  However, one of the worse things you can do is compare your reaction or cycles to another floxed person.  Remember there are no healing timelines set in stone.

Why does the FDA, Doctors, and Politicians allow this travesty to Continue?2023-05-11T14:44:22-05:00

Tragically is it really quite simple.  The FDA, Doctors, and Policy Makers believe Fluoroquinolone Toxicity to be a relatively rare and a recoverable condition. 

When the typical person experiences Fluoroquinolone Toxicity they understand just how horrible it is.  For many their life is a living hell and they want to recover…now.  Many do recover, but unfortunately some do not.  Those that do recover often leave….and never come back.  Again, the truth is that fluoroquinolone toxicity is so horrible, most people want to put it behind and not look back. 

Many doctors do not report adverse effects to the post-marketing surveillance system. According to the most optimistic studies, it is estimated that only one in 20 adverse reactions is reported either on insistence of the patient or by the doctor’s initiative. They are too busy, they are too unsure, and they do not want to be listed as too proactive in drug awareness. The Flox Report states that on average 13 doctors need to be seen before a patient meets one that is willing to listen that fluoroquinolones caused their problems. 

While many people are experiencing fluoroquinolone toxicity, they gravitate to Floxie Hope, a website that publishes stories of recovery and healing.   Sounds great, doesn’t it? The site also talks about how bad these drugs are, so were good right?  It is all well and good until your realize that this is a double edged sword.  FDA, Doctors, Drug Companies and Policy Makers see stories that reinforce the misconceptions of Fluoroquinolone Toxicity.  I refer to this as misguided positivity.  This positivity actually perpetuates a negative situation. This misguided positivity perpetuates the notion that fluoroquinolone toxicity is recoverable and that these drugs are for the most part safe, and that fluoroquinolone toxicity is rare.  It also alienates those who are permanently disabled by these drugs. 

Recently I ran a small poll on this site asking how many visitors who had experienced fluoroquinolone toxicity believed they recovered only to have symptoms emerge later.  Of 139 respondents, 129 voted  Yes (93%, 129 Votes) and only (7%, 10 Votes) voted no.  That is sad, but makes the point that many of these recovery stories you hear are false. 

Listen, I understand the need for hope.  It is essential for the human spirit to survive. But despite this, I am also a realist. This situation will go on indefinitely and people will continue to be harmed perpetuated by the FDA, Doctors, Drug Companies and Policy Makers that believe Fluoroquinolone Toxicity to be a relatively rare and a recoverable condition. 

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