Thank you for watching this video. The following is a list of links to materials documenting the data presented in this video.
Fluoroquinolones damage mammalian mitochondrial DNA via Topoisomerase II:
http://molpharm.aspetjournals.org/content/50/5/1178.long
This article states “These results suggest that ciprofloxacin may be causing cytotoxicity by interfering with a mitochondrial topoisomerase II”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760005/
This article states “quinolones target bacterial gyrases (34) and mtDNA topoisomerases (15),”
Quinolones and damage mammalian mitochondrial DNA:
https://www.myquinstory.info/wp-content/uploads/2010/01/Castora-DNA-Synthesis-In-mam-mtDNA-1983.pdf
FDA’s April 27, 2013 Pharmacovigilance Review, where the FDA notes that the mechanism for action through which fluoroquinolones induce peripheral neuropathy is mitochondrial toxicity.
Fluoroquinolones as adjunct to chemotherapy:
http://infectagentscancer.biomedcentral.com/articles/10.1186/1750-9378-7-33
http://www.nature.com/bjc/journal/v95/n8/full/6603355a.html
https://www.ncbi.nlm.nih.gov/pubmed/10414727
Fluoroquinolone based chemotherapy agents:
https://pubmed.ncbi.nlm.nih.gov/28504025/
Antitumor Power of The Quinolone Antibiotics
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997924/
Article states “quinolones having significant potency against eukaryotic Type II topoisomerases (topo II)”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745469
Ubiquitous Nature of Fluoroquinolones: The Oscillation between Antibacterial and Anticancer Activities
Fluoroquinolones described as chemotherapy
http://pharmaxchange.info/press/2011/05/mechanism-of-action-of-quinolones-and-fluoroquinolones/
“Late Effects” of chemotherapy
http://www.cancer.net/survivorship/long-term-side-effects-cancer-treatment
http://www.mayoclinic.org/diseases-conditions/cancer/in-depth/cancer-survivor/art-20045524
http://ww5.komen.org/BreastCancer/LongTermSideEffectsofChemotherapy.html
GREAT article and video David.
Hello David,
Thanks for this info.
The first two links of the section “Fluoroquinolones described as chemotherapy” are not working.
Also the one under “Fluoroquinolone based chemotherapy agents:”
Thanks for keeping this site and all the work you have done.
Thank you for letting me know. I updated the dead link “Fluoroquinolone based chemotherapy agents:” and I had two remove the two dead links from “Fluoroquinolones described as chemotherapy” as the documentation no longer exists.